RS1805008 MC1R;TUBB3
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What This Variant Does
"rs1805008, known as Arg160Trp or R160W, is one of several SNPs in the MC1R gene associated with red ...
Associated Conditions
Increased analgesia from kappa-opioid receptor agonist
female-specific
Skin/hair/eye pigmentation 2
red hair/fair skin
ALBINISM
OCULOCUTANEOUS
TYPE II
MODIFIER OF
Melanoma
cutaneous malignant
susceptibility to
5
Malignant tumor of breast
SKIN/HAIR/EYE PIGMENTATION
VARIATION IN
GWAS Studies (16)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Red vs. brown/black hair color | T | OR: 12.84 | 2E-308 | PubMed |
| Blond vs. brown/black hair color | T | OR: 1.77 | 2E-308 | PubMed |
| Sunburns | — | — | 2E-225 | PubMed |
| Brown vs. black hair color | T | OR: 1.66 | 1E-76 | PubMed |
| Cutaneous malignant melanoma | T | OR: 1.37 | 2E-73 | PubMed |
| Skin reflectance | T | β: 0.015 | 6E-50 | PubMed |
| Height | T | β: 0.019 | 3E-49 | PubMed |
| Keratinocyte cancer (MTAG) | T | OR: 1.21 | 6E-42 | PubMed |
| Educational attainment (MTAG) | T | β: 0.019 | 2E-15 | PubMed |
| Skin colour saturation | — | β: 0.008 | 1E-13 | PubMed |
| Malignant melanoma | T | OR: 0.26 | 1E-11 | PubMed |
| Hemoglobin levels | T | β: 0.023 | 2E-10 | PubMed |
| White matter microstructure (radial diusivities) | — | — | 9E-10 | PubMed |
| White matter microstructure (fractional anisotropy) | — | — | 2E-9 | PubMed |
| Educational attainment | — | — | 3E-8 | PubMed |
| Skin autofluorescence | T | — | 1E-6 | PubMed |