RS1805007 MC1R
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What This Variant Does
"rs1805007, known as Arg151Cys or R151C, one of several SNPs in the MC1R gene associated with red hai...
Associated Conditions
Skin/hair/eye pigmentation 2
red hair/fair skin
Increased analgesia from kappa-opioid receptor agonist
female-specific
ALBINISM
OCULOCUTANEOUS
TYPE II
MODIFIER OF
Melanoma
cutaneous malignant
susceptibility to
5
SKIN/HAIR/EYE PIGMENTATION
VARIATION IN
2
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Other non-epithelial cancer of skin (PheCode 172.2) | C | OR: 0.38 | 1E-323 | PubMed |
| Actinic keratosis (PheCode 702.1) | C | OR: 0.42 | 4E-319 | PubMed |
| Blond vs. brown/black hair color | T | OR: 1.74 | 2E-308 | PubMed |
| Red vs. brown/black hair color | T | OR: 10.99 | 2E-308 | PubMed |
| Melanomas of skin, dx or hx (PheCode 172.1) | C | OR: 0.41 | 1E-288 | PubMed |
| Skin cancer | C | OR: 0.39 | 8E-269 | PubMed |
| Skin cancer | C | OR: 0.38 | 3E-248 | PubMed |
| Melanomas of skin, dx or hx (PheCode 172.1) | C | OR: 0.42 | 1E-237 | PubMed |
| Degenerative skin conditions and other dermatoses (PheCode 702) | C | OR: 0.26 | 1E-224 | PubMed |
| Other non-epithelial cancer of skin (PheCode 172.2) | C | OR: 0.38 | 9E-224 | PubMed |
| Skin cancer | C | OR: 0.38 | 9E-201 | PubMed |
| Cutaneous malignant melanoma | T | OR: 1.63 | 1E-196 | PubMed |
| Neoplasm of uncertain behavior of skin (PheCode 173) | C | OR: 0.31 | 7E-188 | PubMed |
| Basal cell carcinoma (PheCode 172.21) | C | OR: 0.35 | 2E-151 | PubMed |
| Neoplasm of uncertain behavior of skin (PheCode 173) | C | OR: 0.31 | 2E-150 | PubMed |
| Squamous cell carcinoma (PheCode 172.22) | C | OR: 0.43 | 1E-146 | PubMed |
| Red vs non-red hair color | T | OR: 12.47 | 2E-142 | PubMed |
| Squamous cell carcinoma (PheCode 172.22) | C | OR: 0.44 | 5E-140 | PubMed |
| Degenerative skin conditions and other dermatoses (PheCode 702) | C | OR: 0.25 | 5E-140 | PubMed |
| Keratinocyte cancer (MTAG) | T | OR: 1.35 | 1E-124 | PubMed |
Other Variants in MC1R