RS1804495 SERPINA7

Health Risk Chr X:106034369 snv missense variant

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What This Variant Does

"No known significance [OMIM:THYROXINE-BINDING GLOBULIN, VARIANT P]

Associated Conditions

Thyroxine-binding globulin

variant P

Thyroxine-binding globulin quantitative trait locus

SERPINA7-related disorder

Pancreatic adenocarcinoma

Colorectal cancer

Cholangiocarcinoma

Adrenocortical carcinoma

hereditary

Thyroxine-binding globulin

variant P

Thyroxine-binding globulin quantitative trait locus

SERPINA7-related disorder

Pancreatic adenocarcinoma

Colorectal cancer

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
Thyroxine levels	A	OR: 0.5	3E-106	PubMed
Metabolite levels (thyroxine)	A	OR: 0.37	2E-93	PubMed
Replication initiator 1 levels	A	OR: 0.31	2E-73	PubMed

Population Frequencies

gnomAD ALL

12.9%

1kG AFR

11.1%

1kG ALL

18%

1kG AMR

10.3%

1kG EAS

74.1%

1kG EUR

11.2%

1kG SAS

68.1%

Other Variants in SERPINA7