Genetic variant
rs1801222
rs1801222 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1801222 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1801222, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1801222
- Position
- chr10:17114152
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vitamin B-complex deficiencies (PheCode 261.2) | A | OR 0.22 | 7E-110 | PubMed |
| Vitamin B-complex deficiencies (PheCode 261.2) | A | OR 0.22 | 8E-109 | PubMed |
| Vitamin B12 levels | G | — | 3E-75 | PubMed |
| Other vitamin B12 deficiency anemia (PheCode 281.12) | A | OR 0.19 | 1E-50 | PubMed |
| Megaloblastic anemia (PheCode 281.1) | A | OR 0.18 | 4E-46 | PubMed |
| Other vitamin B12 deficiency anemia (PheCode 281.12) | A | OR 0.19 | 3E-43 | PubMed |
| Other deficiency anemia (PheCode 281) | A | OR 0.14 | 3E-35 | PubMed |
| height (mean, inv-normal transformed) | A | β 0.026 | 7E-20 | PubMed |
| Height (maximum, inv-normal transformed) | A | β 0.026 | 2E-19 | PubMed |
| Vitamin deficiency (PheCode 261) | A | β 0.048 | 6E-19 | PubMed |
| Vitamin deficiency (PheCode 261) | A | β 0.043 | 3E-18 | PubMed |
| height (minimum, inv-normal transformed) | A | β 0.025 | 7E-18 | PubMed |
| Height | A | β 0.005 | 3E-16 | PubMed |
| Height | — | — | 2E-13 | PubMed |
| Vitamin B levels in ischemic stroke | A | OR 0.22 | 2E-13 | PubMed |
| Vitamin B-complex deficiencies (PheCode 261.2) | A | OR 0.18 | 3E-12 | PubMed |
| Standing height (UKB data field 50) | G | β 0.007 | 8E-12 | PubMed |
| Height (baseline) | A | β 0.009 | 6E-11 | PubMed |
| Homocysteine levels | A | β 0.045 | 8E-10 | PubMed |
| Folate pathway vitamin levels | — | β 0.05 | 3E-9 | PubMed |
Sources
- dbSNP: rs1801222 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies