rs1800629 a variant in the TNF gene

What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1800629 is the catalogue number of one of them, in the TNF gene. Which letters you carry there — one copy from each parent — is your genotype.

TNF (tumor necrosis factor): This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

Gene description from NCBI Gene

This SNP in the tumor necrosis factor-alpha gene, rs1800629, is also known as the TNF-308 SNP. Occas...

From SNPedia

Why might it matter?

ClinVar records this variant as drug response, meaning linked to how the body handles certain medicines. A classification describes the variant, not you: what it means for one person depends on their genotype, their family history and often on other genes and circumstances.

Conditions it has been reported with

• etanercept response - Efficacy
• Susceptibility to severe coronavirus disease (COVID-19)
• Human immunodeficiency virus dementia
• Susceptibility to
• Psoriatic arthritis, susceptibility to
• Systemic lupus erythematosus
• Inherited susceptibility to asthma
• Malaria, cerebral
• Endometriosis
• Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF
• Tnfr, and/or TNFR4

Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.

Do I have this variant?

Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

What should I do next?

1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.

This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID

rs1800629

Gene

TNF

Position (GRCh38)

chr6:31575253

Variant type

snv

Consequence

regulatory region variant

ClinVar classification

drug response

Genome-wide association studies (7)

How common the less frequent letter is

gnomAD ALL

87.2%

1kG AFR

88%

1kG ALL

91%

1kG AMR

6.9%

1kG EAS

5.9%

1kG EUR

13.4%

1kG SAS

5.3%

Sources

• dbSNP: rs1800629 — the reference record
• ClinVar — clinical interpretations submitted by laboratories
• SNPedia — community-written summaries
• NCBI Gene: TNF
• Ensembl: TNF
• GWAS Catalog — association studies

Related

Other variants in TNF

• rs281865419
• rs1800750
• rs1799724
• rs1800630

• The TNF gene
• SNP explorer
• Gene directory
• Health conditions