RS1800629 TNF
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What This Variant Does
"This SNP in the tumor necrosis factor-alpha gene, rs1800629, is also known as the TNF-308 SNP. Occas...
Associated Conditions
etanercept response - Efficacy
Susceptibility to severe coronavirus disease (COVID-19)
HUMAN IMMUNODEFICIENCY VIRUS DEMENTIA
SUSCEPTIBILITY TO
Psoriatic arthritis
susceptibility to
Systemic lupus erythematosus
Inherited susceptibility to asthma
Malaria
cerebral
Endometriosis
Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF
TNFR
and/or TNFR4
etanercept response - Efficacy
GWAS Studies (7)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| MHC class I polypeptide-related sequence B levels | A | OR: 0.42 | 3E-28 | PubMed |
| Omega-3 fatty acid levels | A | — | 5E-24 | PubMed |
| Pulse pressure | A | OR: 0.29 | 8E-19 | PubMed |
| Docosahexaenoic acid levels | A | — | 3E-15 | PubMed |
| Omega-3 fatty acid levels | A | — | 1E-14 | PubMed |
| Waist-to-hip ratio adjusted for BMI | A | β: 0.027 | 3E-12 | PubMed |
| Docosahexaenoic acid levels | A | — | 4E-8 | PubMed |
Population Frequencies
gnomAD ALL
87.2%
1kG AFR
88%
1kG ALL
91%
1kG AMR
6.9%
1kG EAS
5.9%
1kG EUR
13.4%
1kG SAS
5.3%
Other Variants in TNF