RS1799971 OPRM1
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What This Variant Does
"The rs1799971(G) allele in exon 1 of the mu opioid receptor OPRM1 gene causes the normal amino acid ...
Associated Conditions
Opioid dependence
susceptibility to
1
Tramadol response
Opioid dependence
susceptibility to
1
Tramadol response
GWAS Studies (14)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Substance use disorder | A | OR: 7.85 | 4E-15 | PubMed |
| Substance use disorder | A | OR: 7.55 | 5E-14 | PubMed |
| Substance use disorder | A | — | 5E-14 | PubMed |
| Opioid use disorder | A | OR: 7.32 | 3E-13 | PubMed |
| Substance use disorder | A | OR: 7.21 | 6E-13 | PubMed |
| Opioid use disorder (broad) | G | OR: 0.89 | 8E-13 | PubMed |
| Opioid use disorder | A | OR: 6.44 | 1E-10 | PubMed |
| Opioid use disorder (broad) | A | OR: 6.17 | 7E-10 | PubMed |
| Opioid use disorder | G | β: 0.07 | 8E-10 | PubMed |
| Opioid use disorder | — | OR: 5.85 | 5E-9 | PubMed |
| Opioid use disorder (MTAG) | — | β: 0.029 | 7E-9 | PubMed |
| Opioid use disorder | — | — | 2E-8 | PubMed |
| Opioid use disorder | — | OR: 5.46 | 5E-8 | PubMed |
| Opioid addiction (multi-trait analysis) | G | OR: 0.11 | 2E-6 | PubMed |
ClinVar Assertions (1)
NM_000914.5(OPRM1):c.118A>G (p.Asn40Asp)
Population Frequencies
gnomAD ALL
84.7%
1kG AFR
0.9%
1kG ALL
22.3%
1kG AMR
20%
1kG EAS
39.3%
1kG EUR
16.2%
1kG SAS
41.8%
Other Variants in OPRM1