Genetic variant
rs1799941
rs1799941 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1799941 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Sex Hormone Regulation [OMIM:SEX HORMONE-BINDING GLOBULIN
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1799941, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1799941
- Position
- chr17:7630105
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Sex hormone-binding globulin levels adjusted for BMI | A | OR 0.12 | 9E-2048 | PubMed |
| Sex hormone-binding globulin levels | — | OR 0.32 | 2E-1854 | PubMed |
| Sex hormone-binding globulin levels | A | OR 0.12 | 4E-1795 | PubMed |
| Total testosterone levels | — | OR 0.21 | 1E-758 | PubMed |
| Total testosterone levels | A | OR 0.2 | 9E-742 | PubMed |
| Total testosterone levels | A | β 0.064 | 2E-424 | PubMed |
| Total testosterone levels | A | OR 0.76 | 1E-300 | PubMed |
| Testosterone levels (UKB data field 30850) | A | β 0.062 | 2E-294 | PubMed |
| Body fat percentage (adjusted for testosterone and SHBG) | — | OR 0.68 | 1E-224 | PubMed |
| Total testosterone levels | G | OR 0.15 | 7E-219 | PubMed |
| Total testosterone levels | A | OR 0.15 | 1E-193 | PubMed |
| Bioavailable testosterone levels | G | β 0.063 | 5E-169 | PubMed |
| Hypogonadism | G | OR 0.24 | 1E-136 | PubMed |
| Hypogonadism | A | OR 0.24 | 4E-122 | PubMed |
| Sex hormone-binding globulin levels | G | OR 0.23 | 5E-86 | PubMed |
| Sex hormone-binding globulin levels | A | OR 0.23 | 6E-75 | PubMed |
| Sex hormone-binding globulin levels | A | OR 0.2 | 4E-48 | PubMed |
| Serum levels of protein SHBG | A | OR 0.24 | 4E-30 | PubMed |
| Serum levels of protein SHBG | A | OR 0.22 | 6E-26 | PubMed |
| Bioavailable testosterone levels | G | β 0.034 | 8E-23 | PubMed |
Sources
- dbSNP: rs1799941 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies