Genetic variant
rs17730281
rs17730281 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17730281 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17730281, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17730281
- Position
- chr15:53615751
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Creatinine levels | A | β 0.026 | 1E-86 | PubMed |
| Estimated glomerular filtration rate (creatinine) | G | β 0.005 | 6E-71 | PubMed |
| Estimated glomerular filtration rate (creatinine) | A | OR 15.88 | 9E-57 | PubMed |
| Blood urea nitrogen (BUN, mean, inv-norm transformed) | G | β 0.041 | 7E-49 | PubMed |
| Estimated glomerular filtration rate | G | OR 13.18 | 1E-39 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | G | β 0.035 | 3E-38 | PubMed |
| Serum creatinine levels | A | β 0.036 | 2E-36 | PubMed |
| Blood urea nitrogen levels | A | β 0.027 | 3E-35 | PubMed |
| creatinine (mean, inv-norm transformed) | G | β 0.036 | 6E-35 | PubMed |
| estimated glomerular filtration rate (eGFR, mean, inv-norm transformed) | G | β 0.036 | 6E-32 | PubMed |
| Blood urea nitrogen (BUN, mean, inv-norm transformed) | G | β 0.033 | 4E-31 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | G | β 0.03 | 6E-28 | PubMed |
| Blood urea nitrogen levels | G | β 0.006 | 2E-25 | PubMed |
| Blood urea nitrogen levels | A | β 0.008 | 2E-24 | PubMed |
| Estimated glomerular filtration rate (cystatin c) | G | β 0.005 | 2E-20 | PubMed |
| Renal failure (PheCode 585) | G | β 0.056 | 2E-19 | PubMed |
| Chronic kidney disease | G | OR 1.08 | 1E-18 | PubMed |
| chloride (minimum, inv-norm transformed) | G | β 0.026 | 6E-17 | PubMed |
| Estimated glomerular filtration rate (creatinine) | G | β 0.003 | 7E-17 | PubMed |
| Urea levels (UKB data field 30670) | A | β 0.019 | 3E-16 | PubMed |
Sources
- dbSNP: rs17730281 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies