Genetic variant
rs17695224
rs17695224 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17695224 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17695224, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17695224
- Position
- chr19:51820963
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| B4GALT1/IFNGR1 protein level ratio | — | OR 0.36 | 3E-489 | PubMed |
| B4GALT1/IL10RB protein level ratio | — | OR 0.32 | 5E-388 | PubMed |
| KLRD1 protein levels | A | OR 0.2 | 1E-306 | PubMed |
| KLRB1/KLRD1 protein level ratio | — | OR 0.26 | 3E-252 | PubMed |
| KLRD1/LY9 protein level ratio | — | OR 0.26 | 5E-246 | PubMed |
| Beta-1,4-galactosyltransferase 1 levels | A | OR 0.29 | 3E-84 | PubMed |
| RGMB/SMOC2 protein level ratio | — | OR 0.14 | 6E-77 | PubMed |
| HSPG2/SMOC2 protein level ratio | — | OR 0.14 | 5E-75 | PubMed |
| ENTPD6 protein levels | A | β 0.075 | 1E-50 | PubMed |
| Type 2 lactosamine alpha-2,3-sialyltransferase levels | A | OR 0.15 | 3E-22 | PubMed |
| Beta-1,4-galactosyltransferase 2 levels | A | OR 0.14 | 2E-21 | PubMed |
| HDL cholesterol levels | A | β 0.029 | 7E-16 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | G | β 0.028 | 3E-15 | PubMed |
| Poly(U)-binding-splicing factor PUF60 levels | A | OR 0.12 | 4E-15 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | G | β 0.027 | 1E-14 | PubMed |
| high density lipoprotein cholesterol (HDLC, minimm, inv-norm transformed) | G | β 0.027 | 1E-14 | PubMed |
| HDL cholesterol | A | β 0.029 | 2E-13 | PubMed |
| HDL cholesterol levels | A | β 0.007 | 4E-9 | PubMed |
Sources
- dbSNP: rs17695224 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies