Genetic variant
rs17522122
rs17522122 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17522122 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17522122, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17522122
- Position
- chr14:32833676
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Educational attainment | T | β 0.012 | 2E-29 | PubMed |
| Metabolic syndrome | — | β 0.013 | 3E-24 | PubMed |
| Body mass index | T | β 0.017 | 8E-24 | PubMed |
| Body mass index | T | β 0.017 | 8E-24 | PubMed |
| Body mass index | T | β 0.022 | 3E-19 | PubMed |
| Whole body fat mass (UKB data field 23100) | T | β 0.02 | 9E-17 | PubMed |
| Type 2 diabetes | G | β 0.034 | 1E-13 | PubMed |
| Cognitive function (baseline) | G | β 0.013 | 2E-13 | PubMed |
| Body mass index | G | β 0.018 | 8E-12 | PubMed |
| C-reactive protein levels (MTAG) | T | β 0.012 | 3E-9 | PubMed |
| Type 2 diabetes | T | OR 1.04 | 3E-9 | PubMed |
| Type 2 diabetes or prostate cancer (pleiotropy) | T | — | 4E-9 | PubMed |
| Body mass index and systole blood pressure (pairwise) | T | — | 5E-9 | PubMed |
| Type 2 diabetes and Attention deficit hiperactivty disorder | — | — | 7E-9 | PubMed |
| Body mass index | G | β 0.016 | 8E-9 | PubMed |
| Body mass index | T | β 0.016 | 9E-9 | PubMed |
| Periodontitis / loose teeth (MTAG) | T | β 0.02 | 1E-8 | PubMed |
| Myopia | T | β 0.063 | 3E-8 | PubMed |
| Body mass index (joint analysis main effects and physical activity interaction) | — | — | 3E-8 | PubMed |
| Cognitive function | — | β 0.031 | 3E-8 | PubMed |
Sources
- dbSNP: rs17522122 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies