Genetic variant
rs17486278
rs17486278 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17486278 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Variants in nicotinic receptors and risk for nicotine dependence. A candidate gene approach identifi...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17486278, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17486278
- Position
- chr15:78575140
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Cancer of bronchus; lung (PheCode 165.1) | A | OR 0.21 | 3E-65 | PubMed |
| Cancer within the respiratory system (PheCode 165) | A | OR 0.2 | 8E-62 | PubMed |
| Emphysema (PheCode 496.1) | A | OR 0.19 | 4E-46 | PubMed |
| Obstructive chronic bronchitis (PheCode 496.21) | A | OR 0.14 | 4E-45 | PubMed |
| Abdominal aortic aneurysm | — | OR 0.1 | 2E-35 | PubMed |
| Chronic obstructive pulmonary disease | C | OR 1.18 | 2E-28 | PubMed |
| Respiratory failure, insufficiency, arrest (PheCode 509) | A | β 0.077 | 8E-21 | PubMed |
| Post bronchodilator FEV1/FVC ratio | A | β 0.017 | 4E-20 | PubMed |
| Atherosclerosis of the extremities (PheCode 440.2) | A | OR 0.1 | 5E-20 | PubMed |
| Atherosclerosis (PheCode 440) | A | β 0.088 | 1E-18 | PubMed |
| Post bronchodilator FEV1 | A | β 0.079 | 3E-18 | PubMed |
| Lung cancer | C | OR 1.25 | 2E-17 | PubMed |
| Lung cancer | C | OR 0.15 | 3E-17 | PubMed |
| Atherosclerosis of native arteries of the extremities with intermittent claudication (PheCode 440.22) | A | OR 0.12 | 5E-17 | PubMed |
| How many years have you or did you smoke cigarettes? (inv-normal transformed) | A | β 0.033 | 3E-16 | PubMed |
| Peripheral vascular disease | A | β 0.061 | 3E-16 | PubMed |
| Respiratory failure (PheCode 509.1) | A | β 0.075 | 3E-16 | PubMed |
| Abdominal aortic aneurysm (PheCode 442.11) | A | β 0.098 | 4E-16 | PubMed |
| Biological Sibling: Cancer, Lung | A | OR 0.11 | 2E-15 | PubMed |
| Chronic airway obstruction (PheCode 496) | A | β 0.096 | 1E-14 | PubMed |
Sources
- dbSNP: rs17486278 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies