Genetic variant

rs174577

rs174577 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174577 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174577, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174577
Position
chr11:61837342

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Omega-3 fatty acids to total fatty acids percentage A OR 0.41 2E-3668 PubMed
Omega-3 fatty acids to total fatty acids percentage A OR 0.37 3E-3618 PubMed
Omega-6 fatty acids to omega-3 fatty acids ratio A OR 0.35 4E-3332 PubMed
Omega-6 fatty acids to omega-3 fatty acids ratio A OR 0.38 1E-3178 PubMed
Omega-3 fatty acids A OR 0.32 6E-2902 PubMed
Omega-3 fatty acids A OR 0.36 3E-2718 PubMed
Docosahexaenoic acid to total fatty acids percentage A OR 0.29 3E-1796 PubMed
Docosahexaenoic acid to total fatty acids percentage A OR 0.26 9E-1664 PubMed
1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6) levels A OR 0.23 2E-97 PubMed
1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4) levels A OR 0.21 1E-85 PubMed
1-arachidonoyl-GPI (20:4) levels A OR 0.19 3E-74 PubMed
Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) C OR 0.15 4E-68 PubMed
Alkenylphosphatidylcholine (P-17:0/20:4) (b) levels A OR 0.39 3E-66 PubMed
Alkenylphosphatidylcholine (P-17:0/20:4) (b) levels A OR 0.38 2E-62 PubMed
Alkenylphosphatidylcholine (P-17:0/20:4) (a) levels A OR 0.37 1E-59 PubMed
Alkenylphosphatidylcholine (P-17:0/20:4) (a) levels A OR 0.36 1E-56 PubMed
Alkylphosphatidylcholine (O-38:5) levels A OR 0.36 2E-56 PubMed
Low density lipoprotein cholesterol levels C β 0.069 2E-54 PubMed
Alkylphosphatidylcholine (O-38:5) levels A OR 0.35 4E-52 PubMed
Phosphatidylcholine (16:0_18:2) levels A OR 0.33 2E-49 PubMed

Sources