Genetic variant

rs174570

rs174570 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174570 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

per the 23andMe blog, the minor allele of this SNP (T) was associated with decreased cholesterol and...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174570, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174570
Position
chr11:61829740

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Height T β 0.023 1E-146 PubMed
Lysophosphatidylethanolamine_22:4_[M-H]1- levels T OR 0.31 6E-110 PubMed
Lysophosphatidylcholine_20:4_[M+H]1+ levels T OR 0.38 1E-106 PubMed
Stearidonic acid levels (275.2014_0.36) — OR 0.3 6E-81 PubMed
Stearidonic acid levels (275.2014_0.36) x waist circumference interaction (2df) — — 1E-78 PubMed
High density lipoprotein cholesterol levels T β 0.061 3E-59 PubMed
Cholesteryl ester_20:5_[M+NH4]1+ levels T OR 0.27 2E-54 PubMed
Phosphatidylethanolamine_38:4_[M-H]1- levels T OR 0.19 8E-52 PubMed
Fatty acid(20:4)_[M-H]1- levels T OR 0.17 1E-50 PubMed
Total cholesterol levels T β 0.053 7E-50 PubMed
Cholesteryl ester_20:3_[M+NH4]1+ levels T OR 0.22 2E-49 PubMed
Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels T OR 0.33 1E-48 PubMed
Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels T OR 0.32 1E-47 PubMed
Apolipoprotein B levels T β 0.051 4E-46 PubMed
Phosphatidylcholine_34:2_[M+OAc]1-/Phosphatidylserine_38:1_[M-H]1- levels T OR 0.19 8E-42 PubMed
Triglyceride levels T β 0.049 2E-41 PubMed
Phosphatidylcholine_34:2_[M+H]1+/Phosphatidylethanolamine_37:2_[M+H]1+/Phosphatidate_39:3_[M+NH4]1+ levels T OR 0.23 2E-41 PubMed
1-(1-enyl-stearoyl)-2-linoleoyl-GPE (p-18:0/18:2) levels T OR 0.2 1E-39 PubMed
Serum alkaline phosphatase levels T β 0.046 5E-38 PubMed
Phosphatidylethanolamine_34:2_[M-H]1- levels T OR 0.22 4E-37 PubMed

Sources