Genetic variant

rs174549

rs174549 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174549 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174549, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174549
Position
chr11:61803910

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Lysophosphatidylethanolamine_22:4_[M-H]1- levels A OR 0.35 2E-263 PubMed
Lysophosphatidylcholine_20:4_[M+H]1+ levels A OR 0.4 3E-234 PubMed
Height A β 0.019 3E-171 PubMed
Cholesteryl ester_20:5_[M+NH4]1+ levels A OR 0.31 8E-139 PubMed
Phosphatidylethanolamine_38:4_[M-H]1- levels A OR 0.22 6E-138 PubMed
Alkenylphosphatidylethanolamine (P-18:1/20:3) (a) levels A OR 0.56 6E-134 PubMed
1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) levels A OR 0.43 2E-119 PubMed
Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels A OR 0.37 3E-119 PubMed
Phosphatidylcholine_36:3_[M+H]1+/Phosphatidylethanolamine_39:3_[M+H]1+/Phosphatidate_41:4_[M+NH4]1+ levels A OR 0.35 3E-116 PubMed
Phosphatidylcholine_38:5_[M+H]1+/Phosphatidylethanolamine_41:5_[M+H]1+/Phosphatidate_43:6_[M+NH4]1+ levels A OR 0.36 2E-113 PubMed
1-oleoyl-2-linoleoyl-GPE (18:1/18:2) levels A OR 0.43 9E-112 PubMed
Fatty acid(20:4)_[M-H]1- levels A OR 0.18 2E-110 PubMed
Diacylglycerol_38:3_[M+H-H2O]1+ levels A OR 0.18 7E-102 PubMed
Alkenylphosphatidylethanolamine (P-18:1/20:3) (a) levels A OR 0.48 1E-96 PubMed
Phosphatidylinositol_36:3_[M-H]1- levels A OR 0.23 2E-91 PubMed
Phosphatidylcholine_35:3_[M+H]1+/Phosphatidylethanolamine_38:3_[M+H]1+/Phosphatidate_40:4_[M+NH4]1+ levels A OR 0.22 1E-90 PubMed
Phosphatidylethanolamine_38:3_[M-H]1- levels A OR 0.16 6E-82 PubMed
Phosphatidylethanolamine_39:4_[M-H]1- levels A OR 0.18 2E-74 PubMed
Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels A OR 0.23 2E-71 PubMed
Fatty acid desaturase activity (serum) A — 2E-70 PubMed

Sources