Genetic variant

rs174547

rs174547 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174547 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial co...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174547, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174547
Position
chr11:61803311

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) C OR 1.69 3E-971 PubMed
lysoPhosphatidylcholine acyl C20:4 levels T OR 42.68 4E-398 PubMed
Phosphatidylcholine diacyl C36:4 levels T OR 37.83 3E-313 PubMed
Lysophosphatidylethanolamine_22:4_[M-H]1- levels C OR 0.35 9E-284 PubMed
Lipid metabolism phenotypes — OR 0.57 8E-262 PubMed
Lysophosphatidylcholine_20:4_[M+H]1+ levels C OR 0.41 7E-261 PubMed
1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) levels C OR 0.46 2E-189 PubMed
Phosphatidylcholine acyl-alkyl C36:5 levels T OR 29.03 2E-185 PubMed
Adrenic Acid levels (331.2643_0.397) — OR 0.41 3E-180 PubMed
Metabolite levels T OR 0.15 7E-179 PubMed
lysoPhosphatidylcholine acyl C20:4 levels T OR 0.17 2E-175 PubMed
Phosphatidylcholine diacyl C38:4 levels T OR 0.14 9E-172 PubMed
Adrenic Acid levels (331.2643_0.397) x waist circumference interaction (2df) — — 4E-163 PubMed
Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) T β 0.07 4E-154 PubMed
Phosphatidylethanolamine_38:4_[M-H]1- levels C OR 0.22 4E-149 PubMed
Cholesteryl ester_20:5_[M+NH4]1+ levels C OR 0.31 4E-148 PubMed
Low density lipoprotein cholesterol levels C β 0.043 2E-143 PubMed
Phosphatidylcholine diacyl C36:4 levels T OR 0.12 9E-141 PubMed
Phosphatidylcholine_37:4_[M+H]1+/Phosphatidylethanolamine_40:4_[M+H]1+/Phosphatidate_42:5_[M+NH4]1+ levels C OR 0.38 5E-130 PubMed
Fatty acid(20:4)_[M-H]1- levels C OR 0.19 9E-122 PubMed

Sources