RS174545 Unknown gene
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What This Variant Does
"Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism"
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Phosphatidylcholine diacyl C38:4 levels | C | OR: 40.67 | 1E-361 | PubMed |
| 1-eicosapentaenoyl-GPC (20:5) levels | C | OR: 0.26 | 1E-137 | PubMed |
| Red blood cell fatty acid levels | — | OR: 0.37 | 8E-90 | PubMed |
| Phosphatidylethanolamine (15-MHDA_18:2) levels | G | OR: 0.45 | 5E-87 | PubMed |
| Total cholesterol levels | G | β: 0.039 | 5E-81 | PubMed |
| Diacylglycerol (18:0_20:4) levels | G | OR: 0.43 | 6E-81 | PubMed |
| Phosphatidylethanolamine (15-MHDA_18:2) levels | G | OR: 0.4 | 1E-69 | PubMed |
| Phosphatidylethanolamine (17:0_18:2) levels | G | OR: 0.38 | 1E-63 | PubMed |
| Metabolite levels | — | OR: 0.54 | 3E-61 | PubMed |
| Phosphatidylethanolamine (17:0_18:2) levels | G | OR: 0.35 | 2E-51 | PubMed |
| Diacylglycerol (18:0_20:4) levels | G | OR: 0.32 | 1E-45 | PubMed |
| red blood cell count (RBC, maximum, inv-norm transformed) | C | β: 0.042 | 2E-38 | PubMed |
| Delta-6 desaturase activity | G | OR: 0.24 | 5E-37 | PubMed |
| 1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) levels | C | OR: 0.16 | 2E-36 | PubMed |
| Triglycerides to total lipids ratio in large LDL | C | β: 0.051 | 1E-35 | PubMed |
| HDL cholesterol levels x short total sleep time interaction (2df test) | — | β: 0.012 | 3E-34 | PubMed |
| HDL cholesterol levels x long total sleep time interaction (2df test) | — | β: 0.012 | 3E-33 | PubMed |
| Phosphatidylcholine (33:2) levels | G | OR: 0.25 | 5E-27 | PubMed |
| Lysophosphatidylcholines (20:4) levels | G | OR: 0.62 | 2E-22 | PubMed |
| Serum metabolite ratios in chronic kidney disease | G | OR: 0.41 | 7E-21 | PubMed |