Genetic variant

rs174545

rs174545 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

Register free Do I have this variant?

What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs174545 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs174545, if your test read this position.

Register free Upload DNA Log in

Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

Upload blood results

What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
Register free Upload DNA Upload blood results Ask Dr. Hemsworth

This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs174545
Position
chr11:61801834

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phosphatidylcholine diacyl C38:4 levels C OR 40.67 1E-361 PubMed
1-eicosapentaenoyl-GPC (20:5) levels C OR 0.26 1E-137 PubMed
Red blood cell fatty acid levels — OR 0.37 8E-90 PubMed
Phosphatidylethanolamine (15-MHDA_18:2) levels G OR 0.45 5E-87 PubMed
Total cholesterol levels G β 0.039 5E-81 PubMed
Diacylglycerol (18:0_20:4) levels G OR 0.43 6E-81 PubMed
Phosphatidylethanolamine (15-MHDA_18:2) levels G OR 0.4 1E-69 PubMed
Phosphatidylethanolamine (17:0_18:2) levels G OR 0.38 1E-63 PubMed
Metabolite levels — OR 0.54 3E-61 PubMed
Phosphatidylethanolamine (17:0_18:2) levels G OR 0.35 2E-51 PubMed
Diacylglycerol (18:0_20:4) levels G OR 0.32 1E-45 PubMed
red blood cell count (RBC, maximum, inv-norm transformed) C β 0.042 2E-38 PubMed
Delta-6 desaturase activity G OR 0.24 5E-37 PubMed
1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) levels C OR 0.16 2E-36 PubMed
Triglycerides to total lipids ratio in large LDL C β 0.051 1E-35 PubMed
HDL cholesterol levels x short total sleep time interaction (2df test) — β 0.012 3E-34 PubMed
HDL cholesterol levels x long total sleep time interaction (2df test) — β 0.012 3E-33 PubMed
Phosphatidylcholine (33:2) levels G OR 0.25 5E-27 PubMed
Lysophosphatidylcholines (20:4) levels G OR 0.62 2E-22 PubMed
Serum metabolite ratios in chronic kidney disease G OR 0.41 7E-21 PubMed

Sources