Genetic variant
rs17157266
rs17157266 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17157266 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17157266, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs17157266
- Position
- chr11:62432345
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Gamma glutamyl transferase levels | T | β 0.045 | 2E-155 | PubMed |
| Gamma glutamyl transpeptidase | C | β 0.041 | 9E-71 | PubMed |
| Gamma glutamyl transferase levels | C | β 0.049 | 9E-57 | PubMed |
| Gamma glutamyl transferase levels | C | β 0.044 | 3E-42 | PubMed |
| Alanine aminotransferase levels | T | β 0.021 | 5E-35 | PubMed |
| Gamma glutamyl transferase levels | C | β 0.039 | 1E-31 | PubMed |
| Alanine aminotransferase levels | C | β 0.034 | 5E-22 | PubMed |
| Gamma glutamyl transferase levels | — | β 0.038 | 3E-17 | PubMed |
| BST2 protein levels | C | β 0.057 | 1E-16 | PubMed |
| Aspartate aminotransferase levels | T | β 0.014 | 7E-15 | PubMed |
| Serum alkaline phosphatase levels | C | β 0.024 | 5E-14 | PubMed |
| Alanine aminotransferase levels | C | β 0.023 | 2E-13 | PubMed |
| GPRC5C protein levels | C | β 0.051 | 5E-12 | PubMed |
| Omega-3 fatty acids to total fatty acids percentage | C | — | 5E-12 | PubMed |
| Omega-3 fatty acids to total fatty acids percentage | C | — | 2E-11 | PubMed |
| Aspartate aminotransferase to alanine aminotransferase ratio | C | β 0.021 | 2E-11 | PubMed |
| Chronic obstructive pulmonary disease-related biomarkers | C | — | 1E-9 | PubMed |
| Linoleic acid levels | C | — | 7E-9 | PubMed |
| Omega-3 fatty acids to Omega-6 fatty acids ratio | C | — | 3E-8 | PubMed |
| Omega-3 fatty acids to Omega-6 fatty acids ratio | C | — | 4E-8 | PubMed |
Sources
- dbSNP: rs17157266 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies