Genetic variant

rs17145750

rs17145750 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs17145750 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs17145750, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs17145750
Position
chr7:73612048

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Triglyceride to HDL cholesterol ratio C OR 0.14 3E-241 PubMed
Triglyceride to HDL cholesterol ratio C OR 0.13 9E-155 PubMed
Cholesteryl Esters to Total Lipids in IDL percentage T β 0.06 6E-122 PubMed
Cholesterol to Total Lipids in Small HDL percentage T β 0.06 2E-115 PubMed
Triglyceride to HDL cholesterol ratio C OR 0.12 8E-113 PubMed
Gamma glutamyl transferase levels T β 0.015 2E-109 PubMed
Cholesteryl Esters to Total Lipids in Small HDL percentage T β 0.05 5E-87 PubMed
Serum urate levels T β 0.052 9E-65 PubMed
FABP4/FGF21 protein level ratio — OR 0.15 6E-63 PubMed
Cholesterol to total lipids in IDL percentage (UKB data field 23610) T OR 0.1 6E-61 PubMed
Average diameter for LDL particles T β 0.04 3E-58 PubMed
Cholesteryl esters to total lipids ratio in IDL C β 0.078 7E-46 PubMed
Cholesteryl esters to total lipids in large HDL percentage (UKB data field 23636) T β 0.087 9E-45 PubMed
Cholesteryl esters to total lipids in IDL percentage (UKB data field 23611) T β 0.085 1E-41 PubMed
Triglycerides to total lipids in large LDL percentage (UKB data field 23618) T β 0.084 3E-41 PubMed
Phospholipids to total lipids ratio in large LDL C β 0.075 7E-41 PubMed
Triglycerides x low social support interaction (2df test) T β 0.008 9E-39 PubMed
Free cholesterol to total lipids ratio in large HDL T β 0.069 2E-36 PubMed
Alkaline phosphatase (UKB data field 30610) T β 0.029 2E-34 PubMed
Reticulocyte count (UKB data field 30250) T β 0.031 5E-34 PubMed

Sources