Genetic variant
rs1558902
rs1558902 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1558902 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1558902, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1558902
- Position
- chr16:53769662
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Weight (maximum, inv-normal transformed) | T | OR 0.14 | 2E-316 | PubMed |
| Type 2 diabetes | A | — | 2E-309 | PubMed |
| Body mass index | A | β 0.081 | 2E-223 | PubMed |
| Body mass index | T | β 0.08 | 6E-222 | PubMed |
| Body mass index | T | β 0.079 | 2E-210 | PubMed |
| Body mass index | A | β 0.082 | 9E-199 | PubMed |
| Body mass index | A | β 0.081 | 1E-156 | PubMed |
| Morbid obesity (PheCode 278.11) | T | OR 0.18 | 7E-122 | PubMed |
| Body mass index | A | OR 0.39 | 5E-120 | PubMed |
| Body mass index | A | OR 0.11 | 1E-107 | PubMed |
| Obesity | A | OR 1.14 | 2E-81 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | T | β 0.043 | 8E-78 | PubMed |
| Metabolic dysfunction-associated steatotic liver disease (MTAG) | T | β 0.077 | 1E-75 | PubMed |
| Waist circumference | A | β 0.073 | 3E-66 | PubMed |
| BMI (adjusted for smoking behaviour) | A | β 0.081 | 7E-65 | PubMed |
| Obstructive sleep apnea (PheCode 327.32) | T | β 0.084 | 3E-63 | PubMed |
| Body mass index (joint analysis main effects and smoking interaction) | A | — | 2E-62 | PubMed |
| Waist circumference | A | β 0.077 | 8E-59 | PubMed |
| Essential hypertension (PheCode 401.1) | T | β 0.078 | 2E-57 | PubMed |
| Hypertension (PheCode 401) | T | β 0.078 | 9E-57 | PubMed |
Sources
- dbSNP: rs1558902 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies