Genetic variant
rs1501908
rs1501908 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1501908 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1501908, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1501908
- Position
- chr5:156971158
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglyceride levels | G | β 0.052 | 9E-40 | PubMed |
| Medication use for hyperlipidemia (number of purchases) | — | β 0.016 | 1E-34 | PubMed |
| Total cholesterol levels | G | β 0.049 | 2E-29 | PubMed |
| Triglycerides | G | β 0.04 | 1E-23 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | C | β 0.02 | 8E-22 | PubMed |
| Low density lipoprotein cholesterol levels | G | β 0.042 | 5E-21 | PubMed |
| Mean reticulocyte volume | C | β 0.022 | 7E-21 | PubMed |
| Triglyceride to phosphoglyceride ratio | G | β 0.028 | 8E-20 | PubMed |
| Medication use (HMG CoA reductase inhibitors) | C | β 0.044 | 7E-17 | PubMed |
| Saturated fatty acids levels | G | — | 6E-16 | PubMed |
| Omega-3 fatty acid levels | G | — | 7E-15 | PubMed |
| Cholesterol to Total Lipids in Medium HDL percentage | C | β 0.02 | 1E-14 | PubMed |
| Hypercholesterolemia | C | OR 0.9 | 6E-13 | PubMed |
| Medication use (HMG CoA reductase inhibitors) | G | β 0.041 | 2E-12 | PubMed |
| Lymphocyte count | C | — | 5E-12 | PubMed |
| Anterior gradient protein 3 levels | C | β 0.093 | 7E-12 | PubMed |
| LDL cholesterol | G | β 0.07 | 1E-11 | PubMed |
| Phospholipids to Total Lipids in Medium HDL percentage | C | β 0.01 | 3E-11 | PubMed |
| Omega-3 fatty acid levels | G | — | 6E-11 | PubMed |
| Total cholesterol levels | — | OR 2.39 | 3E-10 | PubMed |
Sources
- dbSNP: rs1501908 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies