Genetic variant
rs1461729
rs1461729 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1461729 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1461729, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1461729
- Position
- chr8:9329732
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alanine aminotransferase levels | A | β 0.01 | 6E-51 | PubMed |
| Liver enzyme levels (alanine transaminase) | A | β 0.009 | 2E-44 | PubMed |
| Total esterified cholesterol levels | A | β 0.078 | 7E-32 | PubMed |
| Total cholesterol levels | A | β 0.075 | 2E-29 | PubMed |
| Alanine aminotransferase levels | — | β 0.009 | 8E-29 | PubMed |
| Total esterified cholesterol levels (UKB data field 23415) | A | β 0.087 | 2E-26 | PubMed |
| SDC1 protein levels | G | β 0.091 | 1E-25 | PubMed |
| Linoleic acid levels | A | β 0.07 | 2E-25 | PubMed |
| Total cholesterol levels (UKB data field 23400) | A | β 0.083 | 5E-24 | PubMed |
| Sphingomyelins levels | A | β 0.064 | 1E-23 | PubMed |
| Total free cholesterol levels | A | β 0.066 | 5E-23 | PubMed |
| Phospholipids in small LDL | A | β 0.06 | 9E-22 | PubMed |
| Cholesteryl esters to total lipids ratio in large LDL | A | β 0.065 | 3E-21 | PubMed |
| Polyunsaturated fatty acids levels (UKB data field 23446) | A | β 0.077 | 8E-21 | PubMed |
| Omega-6 fatty acids levels | A | β 0.059 | 8E-21 | PubMed |
| Cholesteryl ester levels in large LDL | A | β 0.063 | 1E-20 | PubMed |
| Cholesterol levels in large LDL | A | β 0.063 | 2E-20 | PubMed |
| Cholesterol to total lipids ratio in small LDL | A | β 0.064 | 2E-20 | PubMed |
| Cholesteryl esters to total lipids ratio in large LDL | A | β 0.058 | 3E-20 | PubMed |
| Polyunsaturated fatty acids | A | β 0.058 | 7E-20 | PubMed |
Sources
- dbSNP: rs1461729 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies