Genetic variant
rs144379529 a variant in the IFI27L1 gene
rs144379529 is a single-letter difference in the IFI27L1 gene, on chromosome 14. It has been reported in connection with Susceptibility to severe COVID-19 and Thymoma, among others. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs144379529 is the catalogue number of one of them, in the IFI27L1 gene. Which letters you carry there — one copy from each parent — is your genotype.
IFI27L1 (interferon alpha inducible protein 27 like 1): Predicted to enable molecular adaptor activity. Involved in apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene description from NCBI Gene
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Conditions it has been reported with
- Susceptibility to severe COVID-19
- Thymoma
- Adrenocortical carcinoma, hereditary
- Sarcoma
- Lung cancer
- Familial cancer of breast
- Ovarian serous cystadenocarcinoma
Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs144379529, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs144379529
- Gene
- IFI27L1
- Position
- chr14:94100772
- ClinVar classification
- Likely risk allele
Sources
- dbSNP: rs144379529 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- NCBI Gene: IFI27L1
- Ensembl: IFI27L1