Genetic variant
rs1420101
rs1420101 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1420101 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
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From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1420101, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1420101
- Position
- chr2:102341256
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| eosinophil (absolute count, mean, inv-norm transformed) | C | OR 0.11 | 8E-257 | PubMed |
| Blood protein levels in cardiovascular risk | C | OR 0.58 | 6E-254 | PubMed |
| eosinophil (fraction, maximum, inv-norm transformed) | C | β 0.085 | 6E-182 | PubMed |
| eosinophil (absolute count, minimum, inv-norm transformed) | C | β 0.065 | 9E-116 | PubMed |
| eosinophil (fraction, minimum, inv-norm transformed) | C | β 0.061 | 9E-104 | PubMed |
| eosinophil (fraction, mean, inv-norm transformed) | C | β 0.084 | 3E-58 | PubMed |
| eosinophil (absolute count, mean, inv-norm transformed) | C | β 0.08 | 5E-53 | PubMed |
| eosinophil (fraction, maximum, inv-norm transformed) | C | β 0.077 | 9E-50 | PubMed |
| eosinophil (absolute count, maximum, inv-norm transformed) | C | β 0.07 | 5E-42 | PubMed |
| Asthma | — | OR 1.12 | 5E-32 | PubMed |
| Takes medication for asthma? | C | β 0.098 | 6E-23 | PubMed |
| Asthma | T | OR 1.12 | 4E-21 | PubMed |
| Asthma | T | OR 0.12 | 9E-20 | PubMed |
| PRG3 protein levels | T | β 0.046 | 3E-17 | PubMed |
| Adult asthma | T | OR 1.1 | 8E-15 | PubMed |
| Eosinophil count | A | OR 6.4 | 5E-14 | PubMed |
| Nasal polyps | T | OR 1.15 | 4E-9 | PubMed |
| Inflammatory bowel disease (MTAG) | — | — | 4E-8 | PubMed |
| White blood cell count (eosinophil) | T | β 0.066 | 8E-7 | PubMed |
| White blood cell count (eosinophil) | A | β 0.061 | 5E-6 | PubMed |
Sources
- dbSNP: rs1420101 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies