Genetic variant

rs13538

rs13538 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.

Register free Do I have this variant?

What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs13538 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs13538, if your test read this position.

Register free Upload DNA Log in

Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

Upload blood results

What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
Register free Upload DNA Upload blood results Ask Dr. Hemsworth

This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs13538
Position
chr2:73641201

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Acetylornithine levels A OR 94.66 2E-1984 PubMed
Urine X-12125 levels in chronic kidney disease G OR 1.61 3E-1642 PubMed
N-acetylcitrulline levels G OR 1.01 3E-1022 PubMed
Urine N2-acetyllysine levels in chronic kidney disease G OR 0.87 4E-999 PubMed
N-acetyl-1-methylhistidine levels G OR 0.94 2E-842 PubMed
N2-acetyl,N6-methyllysine levels G OR 0.87 9E-675 PubMed
Urinary metabolite modules (eigenmetabolites) in chronic kidney disease G β 0.035 4E-635 PubMed
Plasma N-delta-acetylornithine levels in chronic kidney disease G OR 0.8 1E-530 PubMed
N-acetylornithine-to-myo-inositol ratio A OR 0.22 5E-498 PubMed
Urine N2,N6-diacetyllysine levels in chronic kidney disease G OR 0.76 1E-453 PubMed
Plasma N-acetyl-1-methylhistidine* levels in chronic kidney disease G OR 0.87 5E-436 PubMed
Plasma N2-acetyl,N6-methyllysine levels in chronic kidney disease G OR 1.34 3E-422 PubMed
Urine N2-acetyl,N6-methyllysine levels in chronic kidney disease G OR 1.18 9E-389 PubMed
Urine oxindolylalanine levels in chronic kidney disease G OR 0.74 2E-340 PubMed
N2-acetyl,N6,N6-dimethyllysine levels G OR 0.64 1E-311 PubMed
Metabolite levels (N-acetylcitrulline) G OR 0.75 5E-303 PubMed
Metabolite levels (N-acetylasparagine) G OR 0.95 5E-303 PubMed
Plasma N-acetyl-2-aminooctanoate* levels in chronic kidney disease G OR 0.62 1E-261 PubMed
Plasma N-acetyltyrosine levels in chronic kidney disease G OR 0.38 9E-218 PubMed
Plasma N-acetylglutamine levels in chronic kidney disease G OR 0.47 3E-197 PubMed

Sources