Genetic variant
rs13143308
rs13143308 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs13143308 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs13143308, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs13143308
- Position
- chr4:110793263
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Atrial flutter (PheCode 427.22) | T | OR 0.32 | 7E-207 | PubMed |
| Ischemic stroke (cardioembolic) | — | — | 2E-47 | PubMed |
| Ischemic stroke (cardioembolic) | — | — | 5E-41 | PubMed |
| Atrial fibrillation and flutter (PheCode 427.2) | T | OR 0.2 | 1E-33 | PubMed |
| Cardioembolic stroke (CCS or TOAST classification) | — | OR 1.21 | 2E-25 | PubMed |
| Cardioembolic stroke (CCSp classification) | — | OR 1.25 | 3E-25 | PubMed |
| Cardioembolic stroke (TOAST classification) | — | OR 1.23 | 6E-24 | PubMed |
| Cardioembolic stroke (CCS and TOAST classification) | — | OR 1.29 | 2E-21 | PubMed |
| Cardioembolic stroke (CCSc classification) | — | OR 1.22 | 4E-20 | PubMed |
| Ischemic stroke | — | — | 1E-15 | PubMed |
| Stroke | — | — | 2E-15 | PubMed |
| Ischemic stroke | — | — | 5E-14 | PubMed |
| Stroke | — | — | 2E-13 | PubMed |
| Electrocardiographic traits (multivariate) | T | — | 5E-9 | PubMed |
| Stroke-specific or cerebrovascular disease code from hospital/death records | T | OR 1.09 | 2E-8 | PubMed |
| Stroke-specific or cerebrovascular disease code from any medical setting | T | OR 1.08 | 1E-7 | PubMed |
| Cerebrovascular disease or stroke | T | OR 1.07 | 3E-7 | PubMed |
| Stroke-specific code from any medical setting | T | OR 1.09 | 8E-6 | PubMed |
Sources
- dbSNP: rs13143308 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies