Genetic variant
rs1303
rs1303 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1303 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
finds no association between rs1303 and pulmonary emphysema [OMIM:PI M3] [GWAS:Metabolite levels]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1303, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1303
- Position
- chr14:94378506
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Glycogen synthase kinase-3 beta (analyte X3236.12) levels | G | OR 0.71 | 2E-151 | PubMed |
| ACP5 protein levels | G | β 0.088 | 3E-56 | PubMed |
| Metabolite levels | — | — | 5E-48 | PubMed |
| Galactokinase levels | G | OR 0.36 | 4E-40 | PubMed |
| PH and SEC7 domain-containing protein 1 levels (PSD.13055.53.3) | G | OR 0.36 | 5E-39 | PubMed |
| Cyclin-dependent kinase-like 2 levels | G | OR 0.4 | 3E-35 | PubMed |
| 39S ribosomal protein L33, mitochondrial levels | G | OR 0.35 | 8E-35 | PubMed |
| ASPN protein levels | G | β 0.066 | 3E-25 | PubMed |
| Cholesteryl Esters to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | G | β 0.02 | 1E-24 | PubMed |
| Free cholesterol to total lipids ratio in small HDL | T | β 0.04 | 9E-19 | PubMed |
| Linoleic acid to total fatty acids percentage | G | β 0.02 | 4E-17 | PubMed |
| Asporin levels | T | OR 0.12 | 6E-17 | PubMed |
| Free cholesterol to total lipids ratio in small VLDL | T | β 0.038 | 7E-17 | PubMed |
| Cholesteryl esters to total lipids ratio in large VLDL | T | β 0.036 | 5E-15 | PubMed |
| Cas scaffolding protein family member 4 levels | G | OR 0.2 | 1E-13 | PubMed |
| mRNA-decapping enzyme 1B levels | G | OR 0.2 | 2E-13 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | β 0.02 | 5E-13 | PubMed |
| Phospholipids to total lipids ratio in small HDL | T | β 0.033 | 6E-13 | PubMed |
| FSTL1 protein levels | G | β 0.048 | 7E-13 | PubMed |
| Cholesteryl esters to total lipids ratio in medium VLDL | T | β 0.032 | 7E-13 | PubMed |
Sources
- dbSNP: rs1303 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies