RS12740374 SORT1
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What This Variant Does
"Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to stat...
Associated Conditions
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 6
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Low density lipoprotein cholesterol levels | — | — | 1E-2031 | PubMed |
| Total cholesterol levels | — | — | 2E-1497 | PubMed |
| Low density lipoprotein cholesterol levels | T | OR: 0.15 | 7E-1290 | PubMed |
| Non-HDL cholesterol levels | — | — | 4E-1189 | PubMed |
| Total cholesterol levels | T | OR: 0.12 | 2E-903 | PubMed |
| Granulins levels | T | OR: 0.86 | 4E-864 | PubMed |
| Non-HDL cholesterol levels | T | OR: 0.14 | 7E-764 | PubMed |
| Complement C1q tumor necrosis factor-related protein 1 levels | T | OR: 0.73 | 2E-530 | PubMed |
| LDL cholesterol | T | OR: 0.12 | 1E-410 | PubMed |
| Phospholipids to Total Lipids in Small HDL percentage | T | β: 0.1 | 3E-366 | PubMed |
| High cholesterol | G | OR: 0.24 | 1E-323 | PubMed |
| Phospholipids in small LDL | T | β: 0.09 | 2E-307 | PubMed |
| Free cholesterol in small LDL | T | β: 0.09 | 7E-300 | PubMed |
| Takes medication for high cholesterol? | G | OR: 0.21 | 6E-297 | PubMed |
| Total cholesterol levels | T | β: 0.093 | 1E-286 | PubMed |
| TNFSF13 protein levels | T | OR: 0.21 | 4E-265 | PubMed |
| Disorders of lipid metabolism (PheCode 272) | G | OR: 0.21 | 7E-262 | PubMed |
| Hyperlipidemia (PheCode 272.1) | G | OR: 0.21 | 6E-259 | PubMed |
| Free Cholesterol to Total Lipids in Small HDL percentage | T | β: 0.08 | 3E-252 | PubMed |
| Low density lipoprotein cholesterol levels | G | OR: 0.18 | 2E-247 | PubMed |