RS12720356 Unknown gene
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What This Variant Does
"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with ...
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| IFNAR1 protein levels | C | OR: 0.17 | 2E-83 | PubMed |
| BST2 protein levels | C | OR: 0.12 | 1E-40 | PubMed |
| IL12RB1 protein levels | C | OR: 0.11 | 5E-36 | PubMed |
| Height | C | β: 0.013 | 4E-30 | PubMed |
| Inflammatory bowel disease | — | OR: 0.15 | 3E-16 | PubMed |
| Inflammatory bowel disease | C | OR: 1.16 | 4E-16 | PubMed |
| Interferon alpha/beta receptor 1 levels | A | OR: 0.18 | 3E-14 | PubMed |
| Crohn's disease | G | OR: 1.12 | 1E-12 | PubMed |
| Ulcerative colitis | C | OR: 1.17 | 2E-11 | PubMed |
| Crohn's disease | C | OR: 1.15 | 3E-11 | PubMed |
| Psoriasis | A | OR: 1.4 | 4E-11 | PubMed |
| Psoriasis | A | OR: 1.25 | 3E-10 | PubMed |
| Rheumatoid arthritis | C | OR: 0.9 | 4E-10 | PubMed |
| Ulcerative colitis | — | OR: 0.14 | 5E-10 | PubMed |
| Whole body fat free mass (UKB data field 23101) | C | β: 0.014 | 6E-10 | PubMed |
| Crohn's disease | — | OR: 0.15 | 1E-9 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | C | OR: 0.87 | 2E-9 | PubMed |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) | — | — | 2E-9 | PubMed |
| Ulcerative colitis vs rheumatoid arthritis (ordinary least squares (OLS)) | — | β: 0.05 | 4E-9 | PubMed |
| Rheumatoid arthritis | C | OR: 0.87 | 8E-9 | PubMed |