Genetic variant
rs12610495
rs12610495 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12610495 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12610495, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12610495
- Position
- chr19:4717660
Genome-wide association studies (12)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| COVID-19 (hospitalized covid vs population) | A | OR 0.15 | 2E-53 | PubMed |
| COVID-19 (critical illness vs population) | A | OR 0.8 | 9E-51 | PubMed |
| COVID-19 (critical illness vs population or mild symptoms) | G | OR 1.3 | 4E-36 | PubMed |
| Height | G | β 0.008 | 2E-32 | PubMed |
| Idiopathic pulmonary fibrosis | G | OR 1.28 | 3E-16 | PubMed |
| Interstitial lung disease | G | OR 1.29 | 2E-12 | PubMed |
| Idiopathic pulmonary fibrosis | G | OR 1.31 | 3E-12 | PubMed |
| COVID-19 (critical illness vs mild symptoms) | — | OR 1.37 | 2E-10 | PubMed |
| COVID-19 (critical illness vs population or mild symptoms) | G | — | 2E-8 | PubMed |
| COVID-19 with respiratory failure requiring mechanical ventilation | G | OR 1.29 | 3E-8 | PubMed |
| COVID-19 with respiratory failure | G | OR 1.22 | 1E-7 | PubMed |
| COVID-19 (hospitalized vs tested, not hospitalized) | G | OR 0.13 | 3E-6 | PubMed |
Sources
- dbSNP: rs12610495 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies