Genetic variant
rs12317268
rs12317268 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12317268 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12317268, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12317268
- Position
- chr12:21199607
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| X-23756 levels | G | OR 0.55 | 4E-169 | PubMed |
| Glycodeoxycholate sulfate levels | G | OR 0.5 | 2E-122 | PubMed |
| Sex hormone-binding globulin levels | — | β 0.088 | 2E-88 | PubMed |
| X-18922 levels | A | OR 0.26 | 1E-71 | PubMed |
| Pregnenolone sulfate levels | A | OR 0.25 | 1E-71 | PubMed |
| X-13429 levels | A | OR 0.14 | 2E-67 | PubMed |
| Taurocholenate sulfate levels | G | OR 0.35 | 4E-65 | PubMed |
| Tetradecanedioate levels | A | OR 0.1 | 4E-60 | PubMed |
| X-14626 levels | A | β 0.054 | 2E-45 | PubMed |
| Urinary metabolite levels in chronic kidney disease | G | OR 0.98 | 2E-29 | PubMed |
| Plasma deoxycholic acid 12-sulfate* levels in chronic kidney disease | G | OR 0.44 | 5E-29 | PubMed |
| 4-androsten-3beta,17beta-diol monosulfate (2) levels | G | OR 0.21 | 2E-24 | PubMed |
| Monounsaturated fatty acid levels | G | — | 3E-23 | PubMed |
| Pregnanediol-3-glucuronide levels | G | OR 0.19 | 1E-19 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 2E-19 | PubMed |
| Hexadecanedioate levels | — | OR 0.82 | 5E-16 | PubMed |
| Serum 25-Hydroxyvitamin D levels (conditioned on BMI) | A | β 0.021 | 2E-14 | PubMed |
| Eicosanoid 14,15-EET, Eicosanoid 5-HETE a levels | — | OR 0.15 | 8E-13 | PubMed |
| Serum 25-Hydroxyvitamin D levels | G | β 0.019 | 9E-12 | PubMed |
| Neutrophil percentage of white cells | G | β 0.02 | 4E-11 | PubMed |
Sources
- dbSNP: rs12317268 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies