Genetic variant
rs11977526
rs11977526 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11977526 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11977526, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11977526
- Position
- chr7:45968511
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| IGF-1 and IGFBP-3 levels (bivariate analysis) | A | — | 3E-195 | PubMed |
| Serum levels of protein IGFBP3 | A | — | 4E-161 | PubMed |
| Pulse pressure | A | OR 0.44 | 5E-139 | PubMed |
| Serum levels of protein IGFBP3 | A | OR 22.24 | 2E-109 | PubMed |
| Insulin-like growth factors | A | — | 3E-101 | PubMed |
| Pulse pressure | A | β 0.009 | 6E-66 | PubMed |
| Serum levels of protein IGFBP3 | A | OR 16.5 | 4E-61 | PubMed |
| Pulse pressure | G | OR 0.39 | 9E-50 | PubMed |
| Systolic blood pressure | A | OR 0.33 | 1E-40 | PubMed |
| Pulse pressure | A | OR 0.36 | 3E-29 | PubMed |
| Pulse pressure | G | OR 0.36 | 1E-21 | PubMed |
| Systolic blood pressure (MTAG) | A | β 0.016 | 8E-20 | PubMed |
| Systolic blood pressure | A | OR 0.38 | 3E-19 | PubMed |
| Insulin-like growth factor-binding protein 3 levels | A | OR 0.2 | 3E-16 | PubMed |
| Blood pressure traits (multi-trait analysis) | A | — | 7E-16 | PubMed |
| Systolic blood pressure | G | β 0.02 | 3E-14 | PubMed |
| Diastolic blood pressure | A | OR 0.11 | 1E-13 | PubMed |
| Diastolic blood pressure | A | β 0.013 | 4E-13 | PubMed |
| Diastolic blood pressure | G | OR 0.17 | 4E-12 | PubMed |
| Systolic blood pressure | A | OR 0.3 | 3E-11 | PubMed |
Sources
- dbSNP: rs11977526 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies