Genetic variant
rs11962800
rs11962800 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11962800 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11962800, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11962800
- Position
- chr6:7886672
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| RWDD1/TXNDC5 protein level ratio | — | OR 0.27 | 2E-138 | PubMed |
| LGALS8/TXNDC5 protein level ratio | — | OR 0.27 | 5E-135 | PubMed |
| MCFD2/TXNDC5 protein level ratio | — | OR 0.26 | 5E-127 | PubMed |
| ENO2/TXNDC5 protein level ratio | — | OR 0.24 | 5E-108 | PubMed |
| CRELD2/TXNDC5 protein level ratio | — | OR 0.23 | 2E-96 | PubMed |
| NUCB2/TXNDC5 protein level ratio | — | OR 0.23 | 2E-95 | PubMed |
| PARK7/TXNDC5 protein level ratio | — | OR 0.22 | 9E-89 | PubMed |
| SEMA4D/TXNDC5 protein level ratio | — | OR 0.2 | 9E-79 | PubMed |
| LBR/TXNDC5 protein level ratio | — | OR 0.2 | 5E-77 | PubMed |
| PTPN6/TXNDC5 protein level ratio | — | OR 0.2 | 2E-74 | PubMed |
| CD69/TXNDC5 protein level ratio | — | OR 0.2 | 6E-74 | PubMed |
| NSFL1C/TXNDC5 protein level ratio | — | OR 0.19 | 7E-73 | PubMed |
| CLEC1B/TXNDC5 protein level ratio | — | OR 0.18 | 2E-59 | PubMed |
| TXNDC5 protein levels | G | OR 0.14 | 6E-49 | PubMed |
| Height | G | β 0.018 | 3E-8 | PubMed |
| Pelvic organ prolapse | A | OR 1.1 | 3E-6 | PubMed |
Sources
- dbSNP: rs11962800 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies