Genetic variant
rs1183910
rs1183910 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1183910 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog each rs1183910(T) lowered CRP by 13.8%
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1183910, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1183910
- Position
- chr12:120983004
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| GGT1/IL1RL2 protein level ratio | — | OR 0.2 | 3E-181 | PubMed |
| Gamma glutamyl transferase levels | — | OR 0.1 | 5E-141 | PubMed |
| C-reactive protein levels or LDL-cholesterol levels (pleiotropy) | A | — | 6E-128 | PubMed |
| C-reactive protein levels or total cholesterol levels (pleiotropy) | A | — | 8E-128 | PubMed |
| C-reactive protein levels | G | OR 0.15 | 2E-124 | PubMed |
| C-reactive protein levels | — | β 0.083 | 2E-77 | PubMed |
| CTSF/CTSV protein level ratio | — | OR 0.12 | 2E-70 | PubMed |
| C-reactive protein levels | — | OR 0.12 | 8E-40 | PubMed |
| AMBP/HYOU1 protein level ratio | — | β 0.093 | 1E-37 | PubMed |
| C-reactive protein | T | OR 13.8 | 1E-30 | PubMed |
| C-reactive protein levels | A | OR 0.13 | 3E-18 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | G | β 0.029 | 8E-17 | PubMed |
| Phosphatidylcholine and other choline levels | A | β 0.034 | 9E-17 | PubMed |
| Triglycerides in medium LDL | A | β 0.034 | 5E-16 | PubMed |
| N-acetylarginine levels | A | β 0.09 | 6E-16 | PubMed |
| Total cholines levels | A | β 0.033 | 2E-15 | PubMed |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 levels | A | β 0.095 | 8E-15 | PubMed |
| Total phosphoglycerides levels | A | β 0.032 | 1E-14 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | G | β 0.027 | 1E-14 | PubMed |
| Gamma-glutamylglutamine levels | A | β 0.081 | 1E-13 | PubMed |
Sources
- dbSNP: rs1183910 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies