Genetic variant
rs11642015
rs11642015 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11642015 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11642015, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11642015
- Position
- chr16:53768582
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body mass index | C | β 0.074 | 4E-315 | PubMed |
| Body mass index | T | β 0.074 | 9E-290 | PubMed |
| Body mass index | — | — | 7E-217 | PubMed |
| Body mass index | T | β 0.076 | 2E-213 | PubMed |
| Arm fat percentage left (UKB data field 23123) | T | β 0.041 | 2E-170 | PubMed |
| Waist circumference | C | β 0.057 | 5E-167 | PubMed |
| Body fat percentage | T | β 0.041 | 7E-165 | PubMed |
| Arm fat percentage right (UKB data field 23119) | T | β 0.04 | 1E-163 | PubMed |
| Whole body fat mass (UKB data field 23100) | T | β 0.065 | 3E-163 | PubMed |
| Obesity (PheCode 278.1) | C | OR 0.14 | 5E-162 | PubMed |
| Metabolic biomarkers (multivariate analysis) | T | — | 2E-157 | PubMed |
| Body fat percentage (UKB data field 23099) | T | β 0.036 | 5E-135 | PubMed |
| BMI and adiposity (confirmatory factor analysis Factor 7) | — | — | 2E-133 | PubMed |
| Leg fat percentage left (UKB data field 23115) | T | β 0.029 | 9E-128 | PubMed |
| Body fat percentage | C | β 0.041 | 1E-112 | PubMed |
| Type 2 diabetes (PheCode 250.2) | C | OR 0.12 | 2E-95 | PubMed |
| Body mass index | T | β 0.077 | 2E-85 | PubMed |
| Body mass index | T | β 0.081 | 2E-81 | PubMed |
| Body mass index variance | — | — | 2E-73 | PubMed |
| Menarche (age at onset) | — | — | 1E-57 | PubMed |
Sources
- dbSNP: rs11642015 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies