Genetic variant
rs1138545
rs1138545 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1138545 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Novel Tenascin-C Haplotype Modifies the Risk for a Failure to Heal After Rotator Cuff Repair.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1138545, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1138545
- Position
- chr9:115073620
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Tenascin levels | T | OR 1.29 | 4E-1960 | PubMed |
| Tenascin (analyte X4155.3) levels | T | OR 1.72 | 3E-910 | PubMed |
| Chymotrypsin-like elastase family member 1 levels | T | OR 0.83 | 3E-579 | PubMed |
| Prolargin levels (PRELP.5675.6.3) | T | OR 1.25 | 2E-489 | PubMed |
| Tenascin (analyte X5675.6) levels | T | OR 1.26 | 2E-388 | PubMed |
| Tenascin (analyte X7131.207) levels | T | OR 0.94 | 2E-193 | PubMed |
| Tenascin levels (TNC.4155.3.2) | T | OR 0.85 | 3E-167 | PubMed |
| GDP-fucose protein O-fucosyltransferase 2 levels (POFUT2.6042.52.3) | T | OR 0.81 | 6E-146 | PubMed |
| Chymotrypsin-like elastase family member 1 levels | T | OR 0.81 | 6E-143 | PubMed |
| Tenascin levels | T | OR 1.23 | 6E-139 | PubMed |
| Tenascin (analyte X6042.52) levels | T | OR 0.72 | 3E-107 | PubMed |
| Tenascin level in Chronic kidney disease with hypertension and no diabetes (4155_3) | T | OR 1.29 | 9E-75 | PubMed |
| Protein eva-1 homolog C levels (EVA1C.7008.13.3) | T | OR 0.59 | 7E-73 | PubMed |
| Tenascin level in Chronic kidney disease with hypertension and no diabetes (5675_6) | T | OR 1.1 | 3E-48 | PubMed |
| Chymotrypsin-like elastase family member 1 level in Chronic kidney disease with hypertension and no diabetes (6107_3) | T | OR 0.92 | 5E-30 | PubMed |
| Hydroxymethylglutaryl-CoA lyase, mitochondrial protein levels (SomaScan ID:4155-3) | T | OR 1.38 | 2E-25 | PubMed |
| Tenascin level in Chronic kidney disease with hypertension and no diabetes (7131_207) | T | OR 0.81 | 2E-22 | PubMed |
| Protein eva-1 homolog C:Cytoplasmic domain levels | T | OR 0.31 | 5E-20 | PubMed |
Sources
- dbSNP: rs1138545 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies