Genetic variant
rs11257655
rs11257655 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11257655 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11257655, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11257655
- Position
- chr10:12265895
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Type 2 diabetes | T | — | 1E-179 | PubMed |
| Type 2 diabetes | T | OR 0.1 | 2E-78 | PubMed |
| Type 2 diabetes | T | OR 1.11 | 7E-78 | PubMed |
| Fasting blood glucose | T | β 0.028 | 3E-65 | PubMed |
| Type 2 diabetes | C | β 0.095 | 1E-63 | PubMed |
| Type 2 diabetes | T | OR 0.11 | 2E-55 | PubMed |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | T | β 0.033 | 9E-50 | PubMed |
| Type 2 diabetes | T | OR 0.12 | 5E-48 | PubMed |
| Hemoglobin A1c levels | T | β 0.034 | 9E-47 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.051 | 5E-44 | PubMed |
| Medication use (drugs used in diabetes) | T | OR 0.11 | 3E-40 | PubMed |
| Hemoglobin A1c (HbA1c, mean, inv-norm transformed) | C | β 0.054 | 2E-39 | PubMed |
| Hemoglobin A1c (HbA1c, maximum, inv-norm transformed) | C | β 0.052 | 1E-37 | PubMed |
| Hemoglobin A1c (HbA1c, minimum, inv-norm transformed) | C | β 0.051 | 3E-37 | PubMed |
| Type 2 diabetes | C | OR 0.12 | 3E-36 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.046 | 1E-35 | PubMed |
| Type 2 diabetes | C | β 0.091 | 7E-35 | PubMed |
| Type 2 diabetes | T | OR 1.09 | 2E-32 | PubMed |
| Type 2 diabetes | T | β 0.092 | 3E-29 | PubMed |
| Type 2 diabetes | T | β 0.086 | 2E-28 | PubMed |
Sources
- dbSNP: rs11257655 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies