Genetic variant
rs11172113
rs11172113 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11172113 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs11172113 is a SNP on ch 12q13.3 in the LRP1 gene. A large GWAS study of over 5,000 patients with m...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11172113, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11172113
- Position
- chr12:57133500
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Migraine | T | OR 1.11 | 1E-90 | PubMed |
| Migraine | C | OR 0.9 | 7E-75 | PubMed |
| Pain (pleiotropy) | — | β 0.043 | 7E-72 | PubMed |
| Headache or migraine | — | — | 1E-62 | PubMed |
| Migraine (MTAG) | — | β 0.035 | 9E-51 | PubMed |
| Migraine and/or pulse pressure | — | — | 2E-50 | PubMed |
| Migraine | T | OR 1.11 | 6E-49 | PubMed |
| Headache | C | β 0.02 | 5E-47 | PubMed |
| Migraine (MTAG) | — | β 0.034 | 4E-44 | PubMed |
| Cervical artery dissection (MTAG) | — | OR 0.33 | 9E-42 | PubMed |
| Pain (pleiotropy) | — | — | 9E-40 | PubMed |
| Migraine | — | OR 1.1 | 6E-36 | PubMed |
| Chronic pain (confirmatory factor analysis Factor 18) | — | — | 2E-35 | PubMed |
| FEV1/FVC ratio | — | — | 3E-35 | PubMed |
| Spontaneous coronary artery dissection | T | OR 1.62 | 9E-31 | PubMed |
| Lung function (FEV1/FVC) | T | OR 11.45 | 2E-30 | PubMed |
| Abdominal aortic aneurysm | — | β 0.091 | 4E-29 | PubMed |
| Lung function (FEV1/FVC) | — | — | 6E-29 | PubMed |
| Migraine | C | OR 0.9 | 1E-28 | PubMed |
| Pain (pleiotropy) | — | — | 2E-27 | PubMed |
Sources
- dbSNP: rs11172113 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies