RS1110400 MC1R

Health Risk Chr 16:89919721 snv missense variant

Upload your DNA to see your genotype for this variant.

What This Variant Does

"CLNSIG=5

Associated Conditions

Melanoma

cutaneous malignant

susceptibility to

SKIN/HAIR/EYE PIGMENTATION

VARIATION IN

Tyrosinase-positive oculocutaneous albinism

Increased analgesia from kappa-opioid receptor agonist

female-specific

Melanoma

cutaneous malignant

susceptibility to

SKIN/HAIR/EYE PIGMENTATION

GWAS Studies (2)

Trait	Risk Allele	OR / Beta	P-value	Study
Red vs. brown/black hair color	C	OR: 10	4E-214	PubMed
Skin colour saturation	—	β: 0.008	1E-13	PubMed

Population Frequencies

gnomAD ALL

1kG AFR

100%

1kG ALL

99.7%

1kG AMR

99.1%

1kG EAS

100%

1kG EUR

99.2%

1kG SAS

99.8%

Other Variants in MC1R