Genetic variant
rs11085824
rs11085824 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11085824 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11085824, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11085824
- Position
- chr19:12890733
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| mean corpuscular hemoglobin (MCH, maximum, inv-norm transformed) | A | β 0.088 | 2E-159 | PubMed |
| BCAM protein levels | G | β 0.092 | 2E-82 | PubMed |
| CA3/HMBS protein level ratio | — | OR 0.12 | 5E-66 | PubMed |
| Mean corpuscular hemoglobin concentration | G | — | 8E-64 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.034 | 2E-62 | PubMed |
| ARG1/HMBS protein level ratio | — | OR 0.11 | 4E-61 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, mean, inv-norm transformed) | A | β 0.044 | 2E-54 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, maximum, inv-norm transformed) | A | β 0.042 | 2E-50 | PubMed |
| ARG1 protein levels | G | β 0.085 | 4E-47 | PubMed |
| PARK7/S100A4 protein level ratio | — | OR 0.1 | 1E-46 | PubMed |
| BLVRB/CA3 protein level ratio | — | β 0.088 | 7E-36 | PubMed |
| MIF/S100A4 protein level ratio | — | β 0.088 | 2E-35 | PubMed |
| GLOD4/S100A4 protein level ratio | — | β 0.086 | 2E-34 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.026 | 2E-31 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.035 | 5E-29 | PubMed |
| Arginine levels | A | OR 10.62 | 2E-26 | PubMed |
| LHPP/PKLR protein level ratio | — | β 0.066 | 4E-21 | PubMed |
| Mean corpuscular volume | — | — | 8E-17 | PubMed |
| Mean corpuscular hemoglobin concentration | G | β 0.029 | 1E-16 | PubMed |
| CA1/TGM2 protein level ratio | — | β 0.059 | 3E-16 | PubMed |
Sources
- dbSNP: rs11085824 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies