Genetic variant

rs11030107

rs11030107 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11030107 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

BDNF and CGRP interaction: Implications in migraine susceptibility

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11030107, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs11030107
Position
chr11:27673288

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Cholesterol to Total Lipids in Medium HDL percentage G β 0.02 2E-22 PubMed
Cholesteryl Esters to Total Lipids in Large HDL percentage G β 0.02 5E-21 PubMed
Cholesterol to Total Lipids in Large HDL percentage G β 0.02 7E-20 PubMed
Polyunsaturated fatty acids to monounsaturated fatty acids ratio G β 0.02 1E-18 PubMed
Cholesteryl Esters to Total Lipids in Medium HDL percentage G β 0.02 2E-18 PubMed
Free Cholesterol to Total Lipids in Medium LDL percentage G β 0.02 6E-18 PubMed
Triglycerides to Total Lipids in Small HDL percentage G β 0.02 7E-18 PubMed
Triglycerides to Total Lipids in Medium HDL percentage G β 0.02 3E-17 PubMed
Monounsaturated fatty acids to total fatty acids percentage G β 0.02 1E-16 PubMed
Triglycerides to Total Lipids in Large HDL percentage G β 0.02 2E-16 PubMed
Degree of unsaturation G β 0.02 3E-16 PubMed
Phospholipid levels in chylomicrons and extremely large VLDL G β 0.02 6E-13 PubMed
Triglycerides in small HDL G β 0.02 7E-13 PubMed
Triglyceride levels A β 0.016 9E-13 PubMed
Triglycerides to Total Lipids in Very Large HDL percentage G β 0.02 2E-12 PubMed
Concentration of chylomicrons and extremely large VLDL particles G β 0.02 2E-12 PubMed
Free cholesterol levels in chylomicrons and extremely large VLDL G β 0.02 3E-12 PubMed
Triglyceride levels (MTAG) A β 0.019 1E-11 PubMed
Total lipid levels in chylomicrons and extremely large VLDL G β 0.02 1E-11 PubMed
Triglycerides in very large VLDL G β 0.01 4E-11 PubMed

Sources