Genetic variant

rs10938397

rs10938397 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10938397 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

obesity and type-2 diabetes *rs1121980 *rs7498665 *rs4752856 *rs17782313 *rs2815752 *rs10938397 The ...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10938397, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs10938397
Position
chr4:45180510

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Body mass index G β 0.031 2E-114 PubMed
Body mass index (MTAG) A β 0.032 1E-87 PubMed
Body mass index A β 0.032 2E-86 PubMed
Body mass index A β 0.032 2E-86 PubMed
Metabolic syndrome — β 0.028 3E-62 PubMed
Body mass index G β 0.038 3E-53 PubMed
Body mass index G β 0.029 1E-49 PubMed
Body mass index A β 0.041 1E-48 PubMed
Body mass index G β 0.035 3E-48 PubMed
Body mass index A β 0.037 1E-47 PubMed
Body mass index — β 0.04 6E-41 PubMed
Body fat percentage G β 0.02 7E-41 PubMed
Type 2 diabetes G — 7E-41 PubMed
Metabolic biomarkers (multivariate analysis) G — 2E-36 PubMed
Obesity G OR 1.12 3E-34 PubMed
Body fat percentage G β 0.021 1E-32 PubMed
Body mass index G OR 0.18 4E-31 PubMed
Waist circumference — β 0.03 8E-29 PubMed
Leg fat percentage right (UKB data field 23111) G β 0.013 1E-27 PubMed
Drinks per week G β 0.009 2E-26 PubMed

Sources