Genetic variant

rs10846744

rs10846744 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10846744 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10846744, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs10846744
Position
chr12:124827879

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Skin yellow/blue component G OR 0.12 2E-59 PubMed
mean corpuscular volume (MCV, mean, inv-norm transformed) G β 0.061 7E-59 PubMed
mean corpuscular hemoglobin (MCH, mean, inv-norm transformed) G β 0.061 2E-56 PubMed
mean corpuscular hemoglobin (MCH, maximum, inv-norm transformed) G β 0.059 2E-54 PubMed
mean corpuscular volume (MCV, minimum, inv-norm transformed) G β 0.058 6E-53 PubMed
mean corpuscular hemoglobin (MCH, minimum, inv-norm transformed) G β 0.056 6E-48 PubMed
Non-HDL cholesterol levels — — 1E-39 PubMed
platelet count (mean, inv-norm transformed) G β 0.049 8E-35 PubMed
X-16935 levels C OR 0.18 6E-33 PubMed
Facial skin colour (CIELAB index b* value) G OR 0.35 5E-32 PubMed
triglyceride (mean, inv-norm transformed) G β 0.046 7E-32 PubMed
Coronary atherosclerosis (PheCode 411.4) G β 0.071 2E-31 PubMed
Low density lipoprotein cholesterol levels — — 2E-30 PubMed
triglyceride (maximum, inv-norm transformed) G β 0.043 1E-29 PubMed
Total bilirubin levels C β 0.021 5E-28 PubMed
platelet count (minimum, inv-norm transformed) G β 0.041 4E-27 PubMed
Coronary atherosclerosis (PheCode 411.4) G β 0.072 1E-26 PubMed
triglyceride (minimum, inv-norm transformed) G β 0.041 1E-25 PubMed
HMOX1 protein levels C β 0.078 1E-25 PubMed
Takes medication for high cholesterol? G β 0.07 2E-25 PubMed

Sources