Genetic variant
rs10830963
rs10830963 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10830963 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs10830963 was associated with an increased risk of type-2 diabetes in our Han Chinese cohort (OR 1....
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10830963, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10830963
- Position
- chr11:92975544
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Fasting glucose | C | β 0.077 | 1E-321 | PubMed |
| Fasting glucose | C | β 0.077 | 1E-211 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.085 | 6E-195 | PubMed |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | G | β 0.057 | 3E-177 | PubMed |
| Fasting blood glucose | G | β 0.067 | 6E-175 | PubMed |
| ICD10 O24.4: Diabetes mellitus arising in pregnancy | C | OR 0.69 | 2E-156 | PubMed |
| Gestational diabetes | — | OR 0.43 | 2E-146 | PubMed |
| Type 2 diabetes | G | — | 4E-132 | PubMed |
| Hemoglobin A1c levels | G | β 0.053 | 1E-127 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.079 | 2E-123 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.064 | 1E-117 | PubMed |
| Fasting blood glucose (BMI interaction) | C | β 0.001 | 4E-105 | PubMed |
| Fasting blood glucose | C | β 0.079 | 2E-100 | PubMed |
| Fasting glucose | C | β 0.078 | 4E-100 | PubMed |
| Fasting glucose | C | β 0.074 | 1E-98 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.063 | 1E-83 | PubMed |
| Fasting glucose | — | — | 3E-77 | PubMed |
| Glycemic traits (pleiotropy) | — | — | 6E-74 | PubMed |
| Fasting glucose adjusted for BMI | C | OR 0.14 | 1E-73 | PubMed |
| Oral glucose tolerance test-1h in pregnancy | G | OR 0.21 | 4E-69 | PubMed |
Sources
- dbSNP: rs10830963 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies