Genetic variant
rs10822184
rs10822184 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10822184 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10822184, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10822184
- Position
- chr10:63577393
Genome-wide association studies (11)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| CXCL11/SDC4 protein level ratio | — | OR 0.11 | 2E-58 | PubMed |
| CLEC1B/VSIR protein level ratio | — | OR 0.1 | 3E-50 | PubMed |
| MED18/TBL1X protein level ratio | — | β 0.079 | 3E-30 | PubMed |
| PPP1R2/TBL1X protein level ratio | — | β 0.079 | 3E-30 | PubMed |
| SMAD1/ZBTB16 protein level ratio | — | β 0.072 | 2E-25 | PubMed |
| CEP85/ZBTB16 protein level ratio | — | β 0.071 | 8E-25 | PubMed |
| PLA2G4A/TBL1X protein level ratio | — | β 0.068 | 3E-22 | PubMed |
| AXIN1/ITGB1BP2 protein level ratio | — | β 0.064 | 9E-21 | PubMed |
| RSPO1/SFRP1 protein level ratio | — | β 0.057 | 8E-17 | PubMed |
| Diastolic blood pressure | T | OR 0.15 | 3E-13 | PubMed |
| Androgen levels | T | β 0.058 | 1E-8 | PubMed |
Sources
- dbSNP: rs10822184 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies