Genetic variant
rs10774625
rs10774625 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10774625 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10774625, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10774625
- Position
- chr12:111472415
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| TNFSF8 protein levels | G | β 0.083 | 3E-54 | PubMed |
| Rheumatoid arthritis or type 1 diabetes | — | — | 3E-43 | PubMed |
| Gout | A | OR 1.07 | 5E-33 | PubMed |
| CSF3R protein levels | G | β 0.065 | 1E-32 | PubMed |
| Smoking initiation | G | β 0.009 | 7E-31 | PubMed |
| sodium (minimum, inv-norm transformed) | A | β 0.028 | 1E-30 | PubMed |
| Coronary artery disease | A | OR 1.06 | 1E-28 | PubMed |
| FCRL2 protein levels | G | β 0.048 | 1E-27 | PubMed |
| Hypothyroidism | — | OR 1.14 | 1E-26 | PubMed |
| SIGLEC8 protein levels | G | β 0.052 | 1E-26 | PubMed |
| LILRB2 protein levels | G | β 0.041 | 1E-24 | PubMed |
| Systolic blood pressure (UKB data field 4080) | G | β 0.019 | 2E-24 | PubMed |
| CD101 protein levels | G | β 0.046 | 9E-24 | PubMed |
| GZMB protein levels | G | β 0.053 | 1E-23 | PubMed |
| Myocardial infarction | A | OR 1.08 | 3E-23 | PubMed |
| Myocardial infarction | — | OR 1.08 | 5E-23 | PubMed |
| ADGRF5 protein levels | G | β 0.053 | 2E-22 | PubMed |
| Body mass index and systole blood pressure (pairwise) | G | — | 4E-22 | PubMed |
| Hypertension (PheCode 401) | A | β 0.054 | 4E-19 | PubMed |
| Aspartate aminotransferase (AST, mean, inv-norm transformed) | A | β 0.026 | 6E-19 | PubMed |
Sources
- dbSNP: rs10774625 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies