Genetic variant
rs10774021
rs10774021 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10774021 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10774021, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10774021
- Position
- chr12:240132
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Deoxycarnitine levels | T | OR 0.35 | 1E-241 | PubMed |
| 1-methylimidazoleacetate levels | T | OR 0.35 | 2E-232 | PubMed |
| Deoxycarnitine levels | C | OR 0.35 | 1E-138 | PubMed |
| Deoxycarnitine levels | T | OR 0.35 | 3E-135 | PubMed |
| 1-methyl-4-imidazoleacetate levels | T | OR 0.36 | 5E-125 | PubMed |
| 1-methylimidazoleacetate levels | C | OR 0.35 | 1E-109 | PubMed |
| 3-aminoisobutyrate levels | T | OR 0.23 | 2E-106 | PubMed |
| Imidazole lactate levels | T | OR 0.21 | 2E-90 | PubMed |
| Estimated glomerular filtration rate (creatinine) | T | β 0.034 | 6E-55 | PubMed |
| Creatinine levels in bottom 99% of individuals by creatinine levels | — | OR 0.37 | 2E-47 | PubMed |
| Plasma deoxycarnitine levels in chronic kidney disease | T | OR 0.1 | 1E-43 | PubMed |
| Imidazole lactate levels | T | OR 0.19 | 1E-34 | PubMed |
| Glutamine degradant levels | T | OR 0.15 | 1E-27 | PubMed |
| Estimated glomerular filtration rate based on creatinine and cystatin C in bottom 99% of individuals by creatinine levels | — | OR 2.57 | 1E-23 | PubMed |
| Bicarbonate (mean, inv-norm transformed) | C | β 0.026 | 1E-22 | PubMed |
| Estimated glomerular filtration rate (creatinine, cystatin c) | T | β 0.021 | 2E-22 | PubMed |
| X-25419 levels | T | OR 0.19 | 5E-22 | PubMed |
| 1-ribosyl-imidazoleacetate (X-11334) levels | C | OR 0.15 | 9E-21 | PubMed |
| Body mass index (BMI, minimum, inv-normal transformed) | C | β 0.025 | 1E-18 | PubMed |
| creatinine (minimum, inv-norm transformed) | C | β 0.021 | 2E-17 | PubMed |
Sources
- dbSNP: rs10774021 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies