Genetic variant
rs10761731
rs10761731 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10761731 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10761731, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10761731
- Position
- chr10:63267850
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean platelet volume | T | OR 0.13 | 6E-659 | PubMed |
| CXCL5/PLXNA4 protein level ratio | — | OR 0.29 | 2E-409 | PubMed |
| CXCL5/SDC4 protein level ratio | — | OR 0.27 | 1E-353 | PubMed |
| Platelet count | T | β 0.074 | 3E-351 | PubMed |
| CD69/PLXNA4 protein level ratio | — | OR 0.28 | 1E-342 | PubMed |
| CXCL5/SERPINE1 protein level ratio | — | OR 0.25 | 8E-310 | PubMed |
| CXCL5/PPIB protein level ratio | — | OR 0.24 | 2E-287 | PubMed |
| CLEC1B/PLXNA4 protein level ratio | — | OR 0.24 | 2E-262 | PubMed |
| CXCL5/CXCL6 protein level ratio | — | OR 0.23 | 4E-262 | PubMed |
| CXCL5/SPARC protein level ratio | — | OR 0.23 | 5E-247 | PubMed |
| platelet count (minimum, inv-norm transformed) | A | β 0.089 | 1E-235 | PubMed |
| Platelet count | T | β 0.062 | 2E-228 | PubMed |
| IKBKG/NFATC1 protein level ratio | — | OR 0.22 | 8E-216 | PubMed |
| platelet count (maximum, inv-norm transformed) | A | β 0.088 | 2E-211 | PubMed |
| HBEGF/PLXNA4 protein level ratio | — | OR 0.21 | 1E-202 | PubMed |
| platelet count (mean, inv-norm transformed) | A | β 0.087 | 3E-178 | PubMed |
| MPIG6B/PLXNA4 protein level ratio | — | OR 0.19 | 9E-159 | PubMed |
| platelet count (minimum, inv-norm transformed) | A | β 0.076 | 2E-150 | PubMed |
| ENO2/PLXNA4 protein level ratio | — | OR 0.18 | 2E-149 | PubMed |
| platelet count (maximum, inv-norm transformed) | A | β 0.075 | 2E-142 | PubMed |
Sources
- dbSNP: rs10761731 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies