Genetic variant
rs10740118
rs10740118 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10740118 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10740118, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10740118
- Position
- chr10:63341447
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| HBEGF/SDC4 protein level ratio | — | OR 0.27 | 5E-333 | PubMed |
| CXCL3/CXCL5 protein level ratio | — | OR 0.25 | 2E-294 | PubMed |
| DKK1/SDC4 protein level ratio | — | OR 0.21 | 4E-202 | PubMed |
| CD69/NFATC1 protein level ratio | — | OR 0.21 | 2E-194 | PubMed |
| PDGFA/SERPINE1 protein level ratio | — | OR 0.2 | 3E-194 | PubMed |
| INPPL1/NFATC1 protein level ratio | — | OR 0.2 | 2E-188 | PubMed |
| DAG1/HBEGF protein level ratio | — | OR 0.19 | 3E-168 | PubMed |
| BANK1/NFATC1 protein level ratio | — | OR 0.19 | 1E-166 | PubMed |
| GP1BA/HBEGF protein level ratio | — | OR 0.19 | 8E-166 | PubMed |
| BCR/NFATC1 protein level ratio | — | OR 0.18 | 5E-146 | PubMed |
| DAG1/F2R protein level ratio | — | OR 0.17 | 1E-132 | PubMed |
| CD69/PTPN6 protein level ratio | — | OR 0.17 | 3E-130 | PubMed |
| ENO2/ITGB1BP2 protein level ratio | — | OR 0.16 | 8E-120 | PubMed |
| EIF4G1/NFATC1 protein level ratio | — | OR 0.16 | 4E-113 | PubMed |
| ITGB1BP2/MITD1 protein level ratio | — | OR 0.16 | 2E-112 | PubMed |
| APP/CCL28 protein level ratio | — | OR 0.15 | 4E-102 | PubMed |
| CCL28/PDGFB protein level ratio | — | OR 0.15 | 4E-101 | PubMed |
| ITGB1BP2/MED18 protein level ratio | — | OR 0.15 | 2E-98 | PubMed |
| AXIN1/NFATC1 protein level ratio | — | OR 0.14 | 1E-95 | PubMed |
| ANGPT1/SERPINE1 protein level ratio | — | OR 0.14 | 8E-93 | PubMed |
Sources
- dbSNP: rs10740118 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies