Genetic variant

rs1065853

rs1065853 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1065853 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Gene-based association study for lipid traits in diverse cohorts implicates BACE1 and SIDT2 regulation in triglyceride levels.

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1065853, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1065853
Position
chr19:44909976

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Free cholesterol in small LDL T OR 0.51 3E-3891 PubMed
Free Cholesterol to Total Lipids in Small LDL percentage T OR 0.47 2E-3832 PubMed
Cholesteryl Esters to Total Lipids in IDL percentage T OR 0.47 3E-3647 PubMed
Triglycerides to Total Lipids in Small LDL percentage T OR 0.45 8E-3449 PubMed
Cholesterol to Total Lipids in IDL percentage T OR 0.45 5E-3399 PubMed
Triglycerides to Total Lipids in IDL percentage T OR 0.43 1E-3203 PubMed
Phospholipids in small LDL T OR 0.46 2E-3173 PubMed
Triglycerides to Total Lipids in Medium LDL percentage T OR 0.43 4E-3109 PubMed
Free Cholesterol in LDL T OR 0.44 4E-2947 PubMed
Phospholipids to Total Lipids in Small VLDL percentage T OR 0.41 4E-2916 PubMed
Triglycerides to Total Lipids in Large LDL percentage T OR 0.41 3E-2876 PubMed
Free cholesterol in medium LDL T OR 0.44 4E-2849 PubMed
Free cholesterol in large LDL T OR 0.42 3E-2776 PubMed
Cholesteryl Esters in IDL T OR 0.42 2E-2754 PubMed
Free Cholesterol to Total Lipids in Small VLDL percentage T OR 0.39 1E-2697 PubMed
Cholesterol in IDL T OR 0.41 2E-2643 PubMed
Cholesterol to Total Lipids in Large LDL percentage T OR 0.4 4E-2641 PubMed
Phospholipids to Total Lipids in Small HDL percentage T OR 0.4 7E-2623 PubMed
Cholesterol to Total Lipids in Small HDL percentage T OR 0.4 1E-2594 PubMed
Cholesteryl Esters to Total Lipids in Very Small VLDL percentage T OR 0.37 4E-2509 PubMed

Sources