RS1061235 HLA-A

Health Risk Chr 6:29945520 snv 3 prime UTR variant

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What This Variant Does

"rs1061235(T) serves as a proxy for the HLA-A*3101 allele. The HLA-A*3101 allele, found in about 2 - ...

Associated Conditions

Carbamazepine hypersensitivity

Medication Interactions

Carbamazepine toxicity strong

HLA-B*1502 proxy — Stevens-Johnson syndrome risk in some populations

GWAS Studies (1)

Trait	Risk Allele	OR / Beta	P-value	Study
Adverse response to carbamazepine	—	OR: 9.12	1E-7	PubMed

Population Frequencies

gnomAD ALL

99.5%

1kG AFR

90.9%

1kG ALL

91.5%

1kG AMR

93.4%

1kG EAS

88.3%

1kG EUR

3.3%

1kG SAS

88.9%